(P 314) RETROSPECTIVE EVALUATION OF DISPARITIES IN ADOLESCENT AND YOUNG ADULT (AYA) PATIENTS WITH SYNOVIAL SARCOMA: A SINGLE INSTITUTION STUDY

Objective: Synovial sarcoma (SS) is a rare and aggressive soft tissue sarcoma predominantly affecting adolescents and young adults (AYA), and accounts for 5-10% of all soft tissue sarcoma. Understanding socioeconomic disparities can provide insight toward differences in presentation and treatment outcomes. An AYA population study showed a higher incidence of SS in white in the US with extremity being the most common site of involvement. Florida is home to a diverse Hispanic population and this study aimed to examine racial/ethnic disparities on survival outcomes.

Methods: We conducted an IRB approved retrospective review of AYA patients (ages 15-39) diagnosed with synovial sarcoma at our institution between 2003 and 2023. Data collected included patient demographics (age, gender, race/ethnicity), socioeconomic status (insurance type), clinical characteristics (tumor size, location, stage), treatment modalities (surgery, radiation, chemotherapy), and outcomes (overall survival). Kaplan-Meier curves were employed for survival analysis with logistic regression models to adjust for confounding variables. Statistical analyses were conducted using R Studio, with a significance threshold of p< 0.05.

Results: A total of 33 AYA patients with synovial sarcoma were included in the study. The cohort was 60.6% female, with a median age of 30 years (15-38 years). Racial/Ethnic distribution was 57.5% Hispanic white, 18% Non-Hispanic White, 21% African American, and 0.3% Asian. Patients were more likely to present with an extremity tumor, have localized disease, and receive systemic treatment with a low occurrence of recurrence, regardless of ethnicity (Table 1). There was also no difference noted in the overall survival between the Hispanics and non-Hispanics (Figure 1)

Conclusion: This small cohort retrospective study was unable to uncover significant disparities in survival outcomes among AYA patients with synovial sarcoma based on ethnicity. Further studies are needed to explore and address any inequities to further improve outcomes for all patients.