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Jinxiu Li, PhD (she/her/hers)

Research Associate
University of Utah
Salt Lake City, Utah, United States

As a cancer researcher at University of Utah, huntsman cancer institute, my research goal is to investigate the development and progression of cancer by utilizing integral multi-omics analysis with human tumors and mouse model and identify druggable targets for cancer therapy based on the cancer multi-omics profiling. I received my Ph.D. training in animal genetics by profiling DNA methylomes and transcriptomes of different chicken species to understand the transcriptional regulation of animal economic traits at China Agricultural University (Li J et al, BMC Genomics, 2015; Li J et al, Front Genet, 2019; Wang Y*, Li J* et al, Poult Sci, 2017, An, J*, Li, J* et al, Genes, 2019).
I am presently conducting research utilizing synovial sarcoma mouse model at Huntsman Cancer Institute. Cancer genomic researches have revealed SWI/SNF chromatin remodeling complexes (BAF complexes) are widely mutated in cancers, which provides opportunities for developing novel cancer therapies. We found that synovial sarcoma driver fusion SS18-SSX incorporation caused degradation of CBAF complexes, which emphasizes the function of fusion containing GBAF and SMARCB1 containing PBAF in synovial sarcoma (Li, J et al, Cancer Discov, 2021).

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