Professor Emeritus
KU Leuven, Belgium
The discovery and functional characterization of new, recurrent cytogenetic or molecular aberrations in malignant disorders are my the most important research objectives.For this research we use the more traditional cytogenetic and molecular methods and the new genome-wide technologies (array CGH, SNP arrays, massive parallel sequencing,…). The identification of new recurrent mutations in malignant disorders allows the development of new tools for diagnosis and/or prediction of prognosis of specific malignant disorders. Above all, new recurrent mutations frequently shed new light on the specific biological mechanisms underlying malignant transformation, and are thus very well suited for development of targeted therapy.
